A surname from Northern Ireland and Scotland, Henderson comes from the name ‘Hendry’ and from ‘Henry.’ The surname Henderson is recognized as the son of Hendry.

The surname can also be spelled .

In Scotland the surname is spelled frequently as Henryson. Most with this surname in Scotland live in the central and eastern regions. Two counties with the most are Lanarkshire and Midlowthian.

Along the English border, the counties of Northumberland and Durham, along with the city of London, have the higher percentage of Henderson families.

The states of Pennsylvania, New York, Georgia, Alabama, Illinois, Ohio, Missouri, California and Texas within the United States have larger numbers of Henderson families.

Famous: Florence Henderson (singer and actress), Bill Henderson (Canadian singer), Dave Henderson (professional football player), Gerald Henderson (professional basketball player), Jackie Henderson (Scottish soccer player), John B. Henderson (19th century U. S. Senator and author of the 13th Amendment), Saffron Henderson (actress from Canada) and Thomas James Henderson (19th century Scottish astronomer).