An English and Irish surname, the Mayo family name comes from the Old French term ‘mahieu’ which would mean little Matthew. The spelling variations for Mayo include Mayow, Mayhew, Mayho and Mayhow. A French spelling for Mayo would be Mailhot. In England the earliest Mayo families lived in Cornwall which is in southwest part of the country. From there the Mayo surname spread to most of England. The populations grew in Lancashire, the city of London, Dorset, Herefordshire, Yorkshire and Gloucestershire with Mayo families. In Scotland the main county with any Mayo family population is Lanarkshire. Within the United States many early Mayo families settled in Massachusetts, Virginia, Maryland, New York, Maine, Georgia and Tennessee. Famous: Charles Horace Mayo (one of the family co-founders of the medical Mayo Clinic), Virginia Mayo (movie film actress), William Mayo (television and radio producer), William Mayo (18th century civil engineer who laid out the city of Richmond, VA), Bob Mayo (musician), William James Mayo (one of the family co-founders of the medical Mayo Clinic), Jerod Mayo (professional football player), Katherine Mayo (journalist), William Worrall Mayo (one of the family co-founders of the medical Mayo Clinic), O. J. Mayo (professional basketball player), Whitman Mayo (actor) and Paul Mayo (professional English footballer).