An English surname, Wilkerson comes from the form of Wilkin. That form of a name comes from the given name of William, meaning resolution and armed. The other forms of spelling for Wilkerson are Wilkins, Wilkiesson and Wilkisson. In England the Wilkerson families are in Lancashire, Yorkshire, Norfolk, Cambridgeshire and the city of London. Only along the western coast of Scotland in Argyll are there any number of Wilkerson families. Within the United States the Wilkerson families are mostly in the mid-west and southern states. Most are found in Oklahoma, Georgia, Texas, Alabama, Missouri, Virginia, Kentucky and Tennessee. Famous: Brad Wilkerson (professional baseball player), William Wilkerson (founder of the Flamingo Hotel), Jerry O. Wilkerson (artist), Mark Wilkerson (rock singer and guitarist) and Tim Wilkerson (auto drag racer).