Mammoth Biosciences Raises $45 Million to Build Next Generation CRISPR Products

Mammoth Biosciences, the company behind the world’s first CRISPR-based disease detection platform, today announced an oversubscribed round of $45 million in Series B funding. The capital will fuel the company’s further development of CRISPR diagnostics and next-generation CRISPR products as it extends its platform to include gene-editing and therapeutics as well.

Mammoth is also exploring deep partnerships with biotech and pharmaceutical companies to leverage the Mammoth’s CRISPR platform to transform healthcare and deliver benefits to patients.

CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeat. It is a technique used to alter DNA. Scientists have learned how to harness CRISPR technology in the lab to make precise changes in genes of organisms such as fruit flies, fish, mice, plants, and even humans. Some find the CRISPR technology to be controversial.

Most biotech companies that do gene-editing use the CRISPR system with Cas-9, a large protein that can cut DNA. Mammoth uses a different protein called Cas-14, which is smaller and more precise than Cas-9. It is useful because of its size and its ability to quickly generate a signal once it finds DNA evidence of disease.

According to Forbes, one of Mammoth’s current partnerships is with UCFS researcher Charles Chiu, who also sits on Mammoth’s scientific advisory board. CRISPR Cas-14 has implications for diagnostics, and Mammoth is interested in creating a diagnostic test for coronavirus.

“As a team on the frontlines of discovery in CRISPR, we’ve seen firsthand the need for new tools to deliver on the therapeutic and diagnostic promise that this technology has to offer,” explained Trevor Martin, CEO and Co-founder of Mammoth Biosciences. “In powering new products in addition to diagnostics, we’re exhibiting the full potential of our platform to read and write the code of life and to fully transform how we interact with biology.”

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